Key points What is the current outlook for performing bilateral salpingectomy for the prevention of ovarian cancer? Findings This systematic review of 158 articles found that salpingectomy was associated with an approximately 80% reduction in ovarian cancer risk ; With widespread implementation, salpingectomy has the potential to reduce ovarian cancer mortality in the US by approximately 15%. It is essential to raise awareness and develop effective implementation strategies; Prospective studies are warranted to demonstrate long-term survival outcomes and feasibility of non-gynecologic surgical procedures. Meaning This review suggests that bilateral salpingectomy for ovarian cancer prevention was safe and feasible and has the potential to be a cost-effective and population-saving strategy. |
Importance
Most ovarian cancers originate in the fimbriated end of the fallopian tube. This has led to the hypothesis that surgical resection of the fallopian tubes at the time of gynecologic and non-gynecologic surgical procedures (known as opportunistic salpingectomy ) may prevent the development of epithelial ovarian cancer in women at average risk. of developing the disease.
Aim
To compile a comprehensive review of the state of the science that examines the current landscape of performing bilateral salpingectomy for the prevention of ovarian cancer.
Evidence Review
A systematic literature review was conducted on March 4, 2022, to identify studies examining salpingectomy for ovarian cancer prevention. This review was conducted in accordance with the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Four databases were selected: PubMed through the National Library of Medicine’s PubMed.gov, Embase through Elsevier’s Embase.com, Cochrane Central Registry of Controlled Trials (CENTRAL) through the Cochrane Library of Wiley and Northern Light Life Sciences Conference Abstracts via Ovid. A total of 20 gray literature sources were also searched, including 1 database, 2 registries, 1 repository, 1 index, 1 archive, 1 preprint server, 1 agency, and 12 organizations.
Findings
The initial search produced 1089 results; A total of 158 publications were included in the final review.
Salpingectomy has been associated with a reduction in the risk of ovarian cancer of approximately 80%.
Studies have shown that salpingectomy was safe, cost-effective, and not associated with an earlier age of onset of menopause.
With widespread implementation, salpingectomy has the potential to reduce ovarian cancer mortality in the US by approximately 15%.
Over the last decade, there has been increasing awareness among both doctors and patients about the adnexa as the source of most ovarian cancers, as well as about the existence of salpingectomy and its potential benefits in reducing the risk of ovarian cancer. ovary. It is essential to raise awareness and develop effective implementation strategies.
Conclusions and relevance The results of this systematic review suggest that bilateral salpingectomy for the prevention of ovarian cancer was safe and feasible and has the potential to be a cost-effective and cost-saving strategy in the entire population. Prospective studies are warranted to demonstrate long-term survival outcomes and feasibility of non-gynecologic surgical procedures. |
