Highlights • Women who undergo medical and invasive treatments for CAD often have worse outcomes than men. • Sex-related differences in treatment outcomes among patients with CAD involve interactions between biological, social, and cultural factors. • More research is needed to improve the application and outcomes of treatment for women with DKA. |
Biological and sociocultural differences between men and women are complex and likely explain most of the variations in the epidemiology and treatment outcomes of coronary artery disease (CAD) between the 2 sexes.
Worse outcomes have been described in women after conservative and invasive CAD treatments. For example, elevated levels of residual platelet reactivity during treatment with antiplatelet drugs, higher rates of adverse cardiovascular outcomes after percutaneous coronary revascularization, and higher operative and long-term mortality after coronary bypass surgery have been reported in women. compared to men.
Despite increasing recognition of sex-specific determinants of outcomes, representation of women in clinical trials remains low and sex-specific management strategies are generally not provided in guidelines.
