Highlights The authors of this systematic review and meta-analysis sought to evaluate the prevalence and impact of sepsis-induced cardiomyopathy. A total of 16 studies were included in the final meta-analysis and the findings show a 20% prevalence of sepsis-induced cardiomyopathy among patients with sepsis. The development of sepsis-induced cardiomyopathy was associated with a significant increase in short-term mortality. The results of this study highlight the significant proportion of patients with sepsis who develop cardiomyopathy and the increased risk of mortality associated with this condition. More research is needed to identify patients at increased risk for sepsis-induced cardiomyopathy, as well as optimal monitoring and management of these patients. |
Aim
The prevalence and its impact on mortality of sepsis-induced cardiomyopathy (SICM) remain controversial. In this systematic review and meta-analysis, we investigated the prevalence and prognosis of sepsis-induced cardiomyopathy (SICM).
Materials and methods
We searched MEDLINE, Cochrane Central Register of Controlled Trials and Embase.
Titles and abstracts were evaluated based on the following criteria: (1) published in English, (2) randomized controlled trials, cohort studies or cross-sectional studies, (3) ≥ 18 years with sepsis, (4) reporting prevalence and /or comparison of short-term mortality between those with and without SICM, defined as new-onset reduction in left ventricular ejection fraction (LVEF) within 72 hours of admission or from sepsis diagnosis.
The random effects model was used for all analyses. This meta-analysis was registered in PROSPERO (CDR42022332896).
Results
Sixteen studies reported the prevalence of sepsis-induced cardiomyopathy (SICM), and the pooled prevalence of SICM was 20% (95% confidence interval [CI], 16-25%; I 2 = 89.9%, P < 0.01).
Eleven studies reported short-term mortality, and SICM was associated with significantly higher short-term mortality (pooled odds ratio: 2.30, 95% CI, 1.43 to 3.69; I 2 = 0%, P = 0.001).
Conclusion
The prevalence of SICM was 20% in patients with sepsis, and the occurrence of SICM was associated with significantly higher short-term mortality.
